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Nature Biotechnology

Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy

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Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y

Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.

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Nature Biotechnology

Unpaired data as a first-order challenge in single-cell and spatial proteomics

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Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8

Unpaired data as a first-order challenge in single-cell and spatial proteomics

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Nature Biotechnology

Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression

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Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

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Nature Biotechnology

High-resolution metagenome assembly for modern long reads with myloasm

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Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03053-z

A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.

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