Nature Biotechnology

Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy

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3 weeks ago

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March 18, 2026

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Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y

Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.

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