Nature Biotechnology
An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03055-x
An engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming. This reshaped tumor microenvironment synergizes with blockade of the immune checkpoint PD-L1 to reinvigorate CD8+ T cells and drive durable tumor regression in mouse models.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology
Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03053-z
A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
Ensuring safety and accountability in China’s biomedical translation system
Blood centers can help biopharma scale cell and gene therapies
Psychedelics at FDA, Mike Davis’ CDER and translating tRNAs — a BioCentury podcast
Suppressor tRNAs take two translational steps forward
FDA could approve psychedelics before redosing is resolved
2026 DIA/FDA Oligonucleotide-Based Therapeutics Conference – 09/23/2026
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Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy
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