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Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors
Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8
We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients treated in phase 1 trials, SSP revealed marked spatial heterogeneity in antibody delivery and target engagement, which was shaped by conserved stromal barriers.