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Programmable control of bacterial operons with a single Cas13 RNA effector
Nature Biotechnology, Published online: 03 June 2026; doi:10.1038/s41587-026-03159-4
The SONAR system enables RNA-level control of bacterial operons using a single engineered Cas13 effector that can be modified to control transcript degradation, translation inhibition and translation activation through simple changes in crRNA design.