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DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage

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STAT+: FDA approves Colorado’s plan to import cheaper drugs from Canada

WASHINGTON — The Food and Drug Administration said Monday that it will allow Colorado to import certain prescription drugs from Canada in an effort to bring prices down for residents, making it the second U.S. state to be granted such authorization. 

Patients have sought out drugs from Canada over the years for relief from the ever-rising costs of American drugs. The first Trump administration officially endorsed the practice in 2020, when it published a regulation allowing states and Indian tribes to propose import plans. The Biden administration affirmed this rule with an executive order in 2021. And Florida became the first state to earn FDA approval in 2024. 

But state importation programs have proved extremely difficult to carry out, even with bipartisan support. Florida has yet to actually import any drugs from Canada, in part due to pushback from the Canadian drug industry and fears the program will affect Canada’s drug supply. In May, the FDA extended its approval by six months to give Florida more time to get its program up and running. 

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WASHINGTON — The Food and Drug Administration said Monday that it will allow Colorado to import certain prescription drugs from Canada in an effort to bring prices down for residents, making it the second U.S. state to be granted such authorization. 

Patients have sought out drugs from Canada over the years for relief from the ever-rising costs of American drugs. The first Trump administration officially endorsed the practice in 2020, when it published a regulation allowing states and Indian tribes to propose import plans. The Biden administration affirmed this rule with an executive order in 2021. And Florida became the first state to earn FDA approval in 2024. 

But state importation programs have proved extremely difficult to carry out, even with bipartisan support. Florida has yet to actually import any drugs from Canada, in part due to pushback from the Canadian drug industry and fears the program will affect Canada’s drug supply. In May, the FDA extended its approval by six months to give Florida more time to get its program up and running. 

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STAT+: Trump’s obesity drug plan creates a temporary Medicare program that may be hard to end

WASHINGTON — Weight loss drugs will be available to adults 65 and older in Medicare for the first time next month, thanks to a government program that’s supposed to be temporary. It may be difficult to end it.

Medicare is prohibited by law from paying for obesity drugs. The Trump administration is circumventing that law by making the drugs available via a demonstration program.

Initially, Medicare had hoped to push private Medicare insurers to voluntarily cover the drugs via a three-year program called BALANCE, which would have started following a short transitional period. But insurers balked, so the federal government is instead extending the transitional coverage program, called Bridge, until the end of next year.

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WASHINGTON — Weight loss drugs will be available to adults 65 and older in Medicare for the first time next month, thanks to a government program that’s supposed to be temporary. It may be difficult to end it.

Medicare is prohibited by law from paying for obesity drugs. The Trump administration is circumventing that law by making the drugs available via a demonstration program.

Initially, Medicare had hoped to push private Medicare insurers to voluntarily cover the drugs via a three-year program called BALANCE, which would have started following a short transitional period. But insurers balked, so the federal government is instead extending the transitional coverage program, called Bridge, until the end of next year.

Continue to STAT+ to read the full story…

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Neumora discards depression asset, lays off staffers after pair of late-stage flops

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Neumora Therapeutics is laying off 35% of workers after its most advanced asset failed a pair of Phase 3 studies, sending the biotech’s stock spiraling early Monday.

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