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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoEpigenetics Underlies Comparatively Accelerated Molecular Aging in Larger and Male Dogs
Large dogs tend to be shorter lived than their smaller counterparts, and a new study found that male and larger dogs undergo accelerated molecular aging, with...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks ago10x Genomics and Fred Hutch partner on cancer technologies
The initiative represents the first time 10x Genomics has widened its clinical research scope past solid tumours to include haematologic malignancies. Under the partnership, the organisations...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoMetabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues
A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a decisive and engineerable determinant of CAR...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoA Flawed Genetic Reference Could Trigger False Alarms in Whole-Genome Screening
Researchers at Semmelweis University show that the standard human reference genome can cause automated whole-genome analyses to flag healthy individuals with false disease variants, highlighting the...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoCompact CRISPR alternative uses bacterial proteins to insert large DNA segments
A new engineered gene-editing system, proven in bacteria and showing promise for use in plants, animals and humans, addresses some limitations of current gene-editing tools, with...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoCaribou to halt CAR-T work, lay off staff amid ‘challenging’ funding climate
Despite having an allogeneic cell therapy prospect that’s ready for late-stage testing in lymphoma, Caribou couldn’t secure funding to support the effort and will now pursue...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoSTAT+: Pharmalittle: We’re reading about WHO obesity guidelines for kids, DOJ targeting pharma, and more
The World Health Organization released its first guidelines addressing the sharp rise in obesity among children and adolescents
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoSTAT+: Caribou Biosciences, biotech co-founded by Jennifer Doudna, is shutting down
Caribou Biosciences is shutting down after failing to raise the money necessary to fund a late-stage clinical trial of its off-the-shelf CAR-T therapy for lymphoma.
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoLock Down the Critical Factors in Oligo and Oligo-Conjugate Characterization with Stunner and Honeybun
This GEN webinar follows oligo quantification from method development through conjugate characterization. The post Lock Down the Critical Factors in Oligo and Oligo-Conjugate Characterization with Stunner...
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Synthetic Biology, Genomics & Advanced Therapeutics3 weeks agoExpanding the Possibilities of Next-Generation Sequencing
Sequencing by expansion (SBX) and Roche’s AXELIOS 1 platform introduce a new approach to single-molecule sequencing, designed to give researchers flexibility across sequencing workflows. The post...
Genmab’s cancer bispecific delivers early survival win in ‘exceedingly positive’ Phase 3 readout
Genmab’s cancer bispecific delivers early OS win in ‘exceedingly positive’ Phase 3 readout
STAT+: HHS moves to allow compounding of some unapproved peptides
Novartis buys Synnovation’s PI3Kα inhibitors for $3 billion
Novartis to pay $2B upfront to take next-gen PI3Kα inhibitor from Synnovation
