Nature Biotechnology
An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03055-x
An engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming. This reshaped tumor microenvironment synergizes with blockade of the immune checkpoint PD-L1 to reinvigorate CD8+ T cells and drive durable tumor regression in mouse models.
Nature Biotechnology
DNA–drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03044-0
New capabilities for controlling drug delivery into cells are developed using DNA–drug conjugates.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology
Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
Illinois’ financial crisis could bring the state to a halt
The final 6 ‘Game of Thrones’ episodes might feel like a full season
New Season 8 Walking Dead trailer flashes forward in time
Mod turns ‘Counter-Strike’ into a ‘Tekken’ clone with fighting chickens
Meet Superman’s grandfather in new trailer for Krypton
Disney’s live-action Aladdin finally finds its stars
BioNTech to shutter Singapore HQ after ‘comprehensive review’
STAT+: Merck’s experimental HIV prevention pill could be made for less than $5 a year, researchers say
A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career
Opinion: STAT+: Former Geisinger CEO: U.S. health systems must replace huge numbers of people with AI
Microplastics in Human Bile Drive Mitochondrial Dysfunction and Senescence
STAT+: Health insurers score major win with higher 2027 Medicare Advantage rates
Illinois’ financial crisis could bring the state to a halt
The final 6 ‘Game of Thrones’ episodes might feel like a full season
New Season 8 Walking Dead trailer flashes forward in time
Mod turns ‘Counter-Strike’ into a ‘Tekken’ clone with fighting chickens
Meet Superman’s grandfather in new trailer for Krypton
Disney’s live-action Aladdin finally finds its stars
-
Uncategorized9 years agoThese ’90s fashion trends are making a comeback in 2017
-
Contributors9 years ago
The final 6 ‘Game of Thrones’ episodes might feel like a full season
-
Uncategorized9 years ago
According to Dior Couture, this taboo fashion accessory is back
-
Uncategorized9 years ago
The old and New Edition cast comes together to perform
-
Uncategorized9 years ago
Phillies’ Aaron Altherr makes mind-boggling barehanded play
-
Uncategorized9 years ago
Uber and Lyft are finally available in all of New York State
-
Uncategorized9 years ago
Disney’s live-action Aladdin finally finds its stars
-
Uncategorized9 years ago
Steph Curry finally got the contract he deserves from the Warriors