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Affordable centimeter-scale 3D microscopy with submicrometer resolution
Nature Biotechnology, Published online: 22 June 2026; doi:10.1038/s41587-026-03209-x
Submicrometer-resolution three-dimensional (3D) imaging of large samples has been constrained by the short working distance, high cost and inflexible design of immersion objectives. We developed hybrid solid–liquid optics (HySIL) — a refractive framework with index-matched components — for submicrometer-resolution 3D imaging of centimeter-scale samples in various immersion media using inexpensive air objectives.