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Helixgate

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Super-potent synthetic opioids called nitazenes are spreading across the U.S.

In high school, Ashley Delgado dreamed of becoming a doctor and one day buying her father a Rolls-Royce. “She wanted to heal people,” said her father, James Taylor. She had a high GPA, Taylor added, and did especially well in science and Latin.  

In her mid-20s, Ashley suffered a leg injury and was prescribed OxyContin. The painkiller marked the beginning of a yearslong descent through addiction — from prescription opioids to methamphetamine, then heroin, and finally, fentanyl.

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In high school, Ashley Delgado dreamed of becoming a doctor and one day buying her father a Rolls-Royce. “She wanted to heal people,” said her father, James Taylor. She had a high GPA, Taylor added, and did especially well in science and Latin.  

In her mid-20s, Ashley suffered a leg injury and was prescribed OxyContin. The painkiller marked the beginning of a yearslong descent through addiction — from prescription opioids to methamphetamine, then heroin, and finally, fentanyl.

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Biogen makes up to $1B immuno play with RayThera takeover

Biogen makes up to $1B immuno play with RayThera takeover

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RayThera will bring three preclinical assets into the Biogen fold, all with anti-inflammatory activity. The most mature of these assets is expected to enter Phase 1 development in Q3.​ ​Read More

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STAT+: In pancreatic cancer, Patrick Soon-Shiong makes promises he has not kept

This is the online version of Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up here to get it delivered to their inbox.

I am entirely enthralled by the World Cup. I am watching a ton of soccer on TV. I love the Tartan Army that has invaded Boston for Scotland’s games at Gillette Stadium. Tiny Cape Verde drawing mighty Spain was incredible. Messi, 39, playing in his sixth (!) World Cup, is still the GOAT. 

And England still hasn’t played but will in a couple of hours, as I get this newsletter finished on Wednesday afternoon. Olé!

Programming note: This newsletter is taking a holiday next week but will be back in your inboxes July 2.

What Soon-Shiong says vs. what he has delivered

I’ve taken a good bit of heat (and hate) from online fans of Patrick Soon-Shiong who view the billionaire physician as a selfless scientist/entrepreneur trying to rid the world of cancer. That’s a laudable goal, of course, except Soon-Shiong’s proclamations are mostly fluff, financially self-serving and have led to FDA wrist-slapping.

A wide gap exists between what Soon-Shiong says his cancer drugs can achieve and what they actually do, based on real clinical evidence.

Pancreatic cancer is an instructive and presently relevant example. Long before Soon-Shiong became rich and famous, he treated diabetic patients with pancreas transplants and performed surgery on patients with pancreatic cancer. A desire to transform the treatment of pancreatic cancer with novel immunotherapies inspired Soon-Shiong’s “Bioshield” mission, according to his own treatise.

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This is the online version of Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up here to get it delivered to their inbox.

I am entirely enthralled by the World Cup. I am watching a ton of soccer on TV. I love the Tartan Army that has invaded Boston for Scotland’s games at Gillette Stadium. Tiny Cape Verde drawing mighty Spain was incredible. Messi, 39, playing in his sixth (!) World Cup, is still the GOAT. 

And England still hasn’t played but will in a couple of hours, as I get this newsletter finished on Wednesday afternoon. Olé!

Programming note: This newsletter is taking a holiday next week but will be back in your inboxes July 2.

What Soon-Shiong says vs. what he has delivered

I’ve taken a good bit of heat (and hate) from online fans of Patrick Soon-Shiong who view the billionaire physician as a selfless scientist/entrepreneur trying to rid the world of cancer. That’s a laudable goal, of course, except Soon-Shiong’s proclamations are mostly fluff, financially self-serving and have led to FDA wrist-slapping.

A wide gap exists between what Soon-Shiong says his cancer drugs can achieve and what they actually do, based on real clinical evidence.

Pancreatic cancer is an instructive and presently relevant example. Long before Soon-Shiong became rich and famous, he treated diabetic patients with pancreas transplants and performed surgery on patients with pancreatic cancer. A desire to transform the treatment of pancreatic cancer with novel immunotherapies inspired Soon-Shiong’s “Bioshield” mission, according to his own treatise.

Continue to STAT+ to read the full story…

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Opinion: Congress should embrace strategic health diplomacy

Whether our nation’s foreign policy is grounded in America First or American exceptionalism, improving global health should be a top policy priority of the United States. The recent hantavirus outbreak and evolving Ebola crisis serve as a reminder to Congress that the well-being of Americans is tied to the well-being of people around the globe.

Two of us, as former U.S. senators, were fortunate to play leading roles in the launch of PEPFAR, the President’s Emergency Plan for AIDS Relief, in 2003. Our research at the Bipartisan Policy Center demonstrated that beyond saving 26 million lives and preventing millions of HIV infections, PEPFAR contributed to a positive opinion of the U.S., better socioeconomic indices, and reduced political instability in target countries compared with non-PEPFAR countries. We termed this effect “strategic health diplomacy” — the idea that by addressing global health, America advances its own national strategic interests.

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Whether our nation’s foreign policy is grounded in America First or American exceptionalism, improving global health should be a top policy priority of the United States. The recent hantavirus outbreak and evolving Ebola crisis serve as a reminder to Congress that the well-being of Americans is tied to the well-being of people around the globe.

Two of us, as former U.S. senators, were fortunate to play leading roles in the launch of PEPFAR, the President’s Emergency Plan for AIDS Relief, in 2003. Our research at the Bipartisan Policy Center demonstrated that beyond saving 26 million lives and preventing millions of HIV infections, PEPFAR contributed to a positive opinion of the U.S., better socioeconomic indices, and reduced political instability in target countries compared with non-PEPFAR countries. We termed this effect “strategic health diplomacy” — the idea that by addressing global health, America advances its own national strategic interests.

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