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STAT+: At AACR, talk of Chinese biotech, oncology’s comms issue, and more
You’re reading the web version of STAT’s popup newsletter, AACR in 30 seconds, your guide to what’s happening at the American Association of Cancer Researchers’ annual meeting.
This is the last edition of our pop-up newsletter. We hope you’ve learned as much as we have. If you’re not already a STAT+ subscriber, consider it! There’s currently a 60% off promotion on annual subscriptions.
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Overcoming resistance and RevMed’s next drug?
In case you missed it, Revolution Medicines’ sessions yesterday were jam-packed with conference attendees. While most of the media coverage focused on the daraxonrasib in frontline pancreatic cancer data, the company also revealed some activity in a new compound, RM-055. CEO Mark Goldsmith described it as being part of a new class of “catalytic inhibitors,” since it can slice off a phosphate from GTP-RAS, or the “on” form of RAS, and turn the protein off.
This generated a lot of interest because one of the main ways that cancer develops resistance to RAS inhibitors is by amplifying mutant RAS, basically flooding the cell with the oncoprotein and overwhelming the inhibitor. RM-055, with its catalytic ability to turn multiple mutant RAS proteins off, may be the next step in the arms race against RAS-addicted cancer.
Uncategorized
STAT+: Publicly, Kennedy embraces a more moderate MAHA
WASHINGTON — Health secretary Robert F. Kennedy Jr. once said there are no vaccines that are safe and effective. On Wednesday, he seemed to have changed his tune.
Across two Senate hearings, Kennedy noted that as health secretary, he funded the development of new vaccines, green-lit new shots for patients, asserted flu vaccines are preventive care, and even urged “every child to get the MMR,” a shot he previously suggested wasn’t safe. Last week, he acknowledged the shot could have saved the life of a child who died of measles.
Kennedy’s agenda continues to make waves across American health care, as his department pursues a broad crackdown on fraud and seeks to upend Americans’ relationship with ultra-processed foods — all after major cuts across health agencies and a reworking of vaccine policy. But the about-face expands to a number of core MAHA issues — chemicals in food and the government’s relationship with industry among them.
It comes as some leaders of the insurgent movement have grown skeptical of the administration they rallied to support, forcing the Trump administration to thread the needle between courting the MAHA base’s ongoing support and dropping MAHA priorities seen as impractical or politically unwise.
WASHINGTON — Health secretary Robert F. Kennedy Jr. once said there are no vaccines that are safe and effective. On Wednesday, he seemed to have changed his tune.
Across two Senate hearings, Kennedy noted that as health secretary, he funded the development of new vaccines, green-lit new shots for patients, asserted flu vaccines are preventive care, and even urged “every child to get the MMR,” a shot he previously suggested wasn’t safe. Last week, he acknowledged the shot could have saved the life of a child who died of measles.
Kennedy’s agenda continues to make waves across American health care, as his department pursues a broad crackdown on fraud and seeks to upend Americans’ relationship with ultra-processed foods — all after major cuts across health agencies and a reworking of vaccine policy. But the about-face expands to a number of core MAHA issues — chemicals in food and the government’s relationship with industry among them.
It comes as some leaders of the insurgent movement have grown skeptical of the administration they rallied to support, forcing the Trump administration to thread the needle between courting the MAHA base’s ongoing support and dropping MAHA priorities seen as impractical or politically unwise.
Uncategorized
STAT+: Federal test of AI prior authorization is delaying care for seniors, report says
Washington state hospitals say their Medicare patients are waiting two to four times longer in some cases for procedures that are now subject to prior authorization under a new Medicare program.
The report from U.S. Sen. Maria Cantwell (D-Wash.) is among the first to document alleged patient harm stemming from the Centers for Medicare and Medicaid Services’ new Wasteful and Inappropriate Service Reduction, or WISeR, Model. Cantwell is one of several Democratic members of Congress who have been urging CMS to scrap the program, which launched Jan. 1.
Cantwell aired her concerns about WISeR to Health and Human Services Secretary Robert F. Kennedy Jr. at a Senate Finance Committee hearing on Wednesday. She said CMS is using AI as a “denial device” and that patients are waiting weeks to get approval for services that previously didn’t require approval.
Washington state hospitals say their Medicare patients are waiting two to four times longer in some cases for procedures that are now subject to prior authorization under a new Medicare program.
The report from U.S. Sen. Maria Cantwell (D-Wash.) is among the first to document alleged patient harm stemming from the Centers for Medicare and Medicaid Services’ new Wasteful and Inappropriate Service Reduction, or WISeR, Model. Cantwell is one of several Democratic members of Congress who have been urging CMS to scrap the program, which launched Jan. 1.
Cantwell aired her concerns about WISeR to Health and Human Services Secretary Robert F. Kennedy Jr. at a Senate Finance Committee hearing on Wednesday. She said CMS is using AI as a “denial device” and that patients are waiting weeks to get approval for services that previously didn’t require approval.
OpenAI is launching ChatGPT for Clinicians, a free tool for doctors, nurse practitioners, physician assistants and pharmacists.
It’s the latest product the AI giant has launched within healthcare, after the company announced …
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STAT+: Publicly, Kennedy embraces a more moderate MAHA
STAT+: Federal test of AI prior authorization is delaying care for seniors, report says
OpenAI’s head of health lays out the AI giant’s healthcare ambitions
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STAT+: At AACR, talk of Chinese biotech, oncology’s comms issue, and more
Illinois’ financial crisis could bring the state to a halt
The final 6 ‘Game of Thrones’ episodes might feel like a full season
New Season 8 Walking Dead trailer flashes forward in time
Mod turns ‘Counter-Strike’ into a ‘Tekken’ clone with fighting chickens
Meet Superman’s grandfather in new trailer for Krypton
Disney’s live-action Aladdin finally finds its stars
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