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Google DeepMind and Edison Are Building the AI Scientist

Google DeepMind and Edison Are Building the AI Scientist

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Google DeepMind and Edison Scientific are on an ambitious mission to build the AI scientist. These platforms propose to automate the scientific method using reasoning systems that connect hypothesis generation, experimental design, and data interpretation in one platform. In drug discovery, where traditional development timelines can stretch beyond a decade, such systems promise to dramatically accelerate the pace of biomedical research.

The AlphaFold developer and the nonprofit home organization behind Edison, FutureHouse, originally introduced their respective systems, Co-Scientist and Robin, as bioRxiv preprints in early 2025. Those studies have now been published in Nature, marking another step toward a growing ecosystem of specialized AI agents for life science research. 

Led by Demis Hassabis, PhD, CEO, and 2024 Nobel laureate in Chemistry, DeepMind is no stranger to expanding biomedicine. The team published a January Nature paper describing AlphaGenome, a unifying DNA sequence model for regulatory variant-effect prediction to support understanding of genome function and disease biology. 

Additionally, DeepMind drug discovery spinout, Isomorphic Labs, recently made waves after securing a whopping $2.1 billion Series B led by Thrive Capital, signaling the industry’s growing investment in AI-driven therapeutics. 

“I’ve always believed the No.1 application of AI should be to improve human health,” wrote Hassabis on LinkedIn when announcing Isomorphic’s blockbuster raise. 

DeepMind’s newly published AI assistant, Co-Scientist, is a general-purpose multi-agent system built with Google’s Gemini and driven by natural language prompts. The platform demonstrated initial validation across three biomedical applications: drug repurposing for acute myeloid leukemia, novel target discovery for liver fibrosis, and explaining mechanisms of anti-microbial resistance. 

Co-Scientist’s design scales test-time compute to iteratively reason, evolve, and improve the output as it gathers more knowledge. Researchers can also actively steer the system by refining generated ideas or providing feedback through the natural language chat.

Vivek Natarajan, research scientist at DeepMind, emphasizes that time is a valuable commodity when tackling disease. Co-Scientist aims to support humans scientists in reaching answers to their problems much faster than before, from “months and years to minutes and hours.”

“To realize this vision, we need to build in reliability, trustworthiness and ensure a collaborative human-AI interaction paradigm. We have done a lot of research on these aspects and we are continuing to improve,” Natarajan told GEN Edge.

Closing the loop 

Edison is the commercial spinout of FutureHouse, an AI scientist non-profit backed by former Google CEO Eric Schmidt and co-founded by Sam Rodriques, PhD, former group leader at The Francis Crick Institute and Edison’s CEO. The team’s newly published platform, Robin, leverages both OpenAI o4-mini and Anthropic Claude 3.7 to aid biological discovery.  

In research tasks, Robin proposed repurposing Ripasudil, an existing drug for treatment of glaucoma, to address dry age-related macular degeneration (dAMD) via a novel mechanism that enhanced retinal pigment epithelial cell phagocytosis. The platform also suggested a circadian clock modulator, KL001, as an unexpected treatment for dAMD, illustrating the ability to make new connections not found in existing literature. Both insights were experimentally validated in patient-derived retinal pigment epithelium (RPE) cells. 

Since Robin’s May 2025 preprint release, Edison unveiled an updated AI scientist, Kosmos, last November. Kosmos can reason over 175 million full-text papers, clinical trials and patents, and operate interactively as a colleague that can sends updates mid-run. The system is reported to perform hundreds of research tasks in parallel to compress months of work into a single day.  

Today, Edison announced a collaboration with Incyte to employ Kosmos across the global pharma’s discovery and development pipeline. The partnership will focus on enabling continuous learning from translational and clinical data, real-time synthesis of evidence, and predictive models of therapeutic performance.

Michaela Hinks, founding member of technical staff at Edison, says the main bottlenecks for AI scientist adoption are trust, validation, and the gap in end-to-end solutions.  

“Most AI tools accelerate the cheaper and easier upstream work, but not the expensive and regulated downstream stages of scientific research,” Hinks told GEN Edge. 

She also highlights Robin as the first demonstration of an agentic AI scientist generating a hypothesis that is tested and validated in patient-derived cells, not an immortalized cell line, supporting clinically actionable insights for patients in need. 

Whether AI scientists will truly revolutionize discovery remains to be seen, but researchers are already beginning the experiment.  

The post Google DeepMind and Edison Are Building the AI Scientist appeared first on GEN – Genetic Engineering and Biotechnology News.

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New webinar: Tackling drug discovery challenges in cancer research

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Cancer cells

Hosted by Drug Discovery World and supported by Sartorius and BioIVT, this webinar will explore the opportunities and challenges that exist within cancer research drug discovery and development.

You will hear from Dr Sudha Rao, Chief Scientific Officer of Kazia Therapeutics, Karol Budzik, PhD, Business Development Associate at Vyriad Therapeutics and Lars van der Veen, Chief Scientific Officer at iOnctura.

Presentations will cover how cancer treatments have shifted towards reprogramming the biology driving tumour growth, immune escape and treatment resistance, the trajectory that in vivo CAR-T treatments are taking, and how challenging tumours burdened by stroma and immune-mediated resistance can be tackled.

Q&A with the speakers follows the presentations.

Register for free now.

The post New webinar: Tackling drug discovery challenges in cancer research appeared first on Drug Discovery World (DDW).

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Psilocybin proves promising in neuropathic pain mouse study

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Amid the rise of psychedelics in the mental health space, researchers have begun to explore psilocybin as a treatment for chemotherapy-induced peripheral neuropathy.

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New Spectrometry Technique Could Aid Formulation Development

New Spectrometry Technique Could Aid Formulation Development

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A new technique combining two forms of spectrometry could help biopharmaceutical companies improve their choice of formulation buffer for antibody manufacturing by revealing how molecular forms and three-dimensional shapes of complex biologics respond to their environment. That’s the view of Christian Bleiholder, PhD, a professor at Florida State University who helped develop the technique.

According to Bleiholder, what happens structurally when a complex biological molecule, such as an antibody or viral spike protein, binds to its target is currently poorly understood.

“This is where [this approach] can help with the bioprocessing and formulation,” he says, as structural changes “can affect the lifespan [of the product] and lead to issues, such as aggregation.”

Because antibodies are complex, existing techniques tend to be powerful at different levels of complexity, he explains. Mass spectrometry is particularly powerful for distinguishing molecular composition, while structural approaches such as X-ray crystallography and cryo-electron microscopy can provide high-resolution structural information.

The challenge is understanding the link between these things within a heterogeneous sample, he says.

To overcome this, Bleiholder and his team worked with Bruker Daltonics to develop Tandem-Trapped Ion Mobility Spectrometry (Tandem-TIMS). This combines tandem ion mobility spectrometry with tandem mass spectrometry to disentangle three overlapping layers of molecular complexity: molecular form, three-dimensional shape, and binding or assembly state, he says.

He explains that, if the proteins have different structures, they can be characterized with tandem ion mobility spectrometry, and then mass spectrometry can be used to look at their molecular forms and binding states.

Going forward, Bleiholder hopes the technique can be used for formulation development but also earlier, during drug discovery of new products, such as multi-specific antibodies, to determine which molecular states are important and how those change when a biologic engages its target. He also plans to look at automating the technique.

Bleiholder spoke about using Tandem-TIMS at the Bioprocessing Summit in Boston earlier this year.

The post New Spectrometry Technique Could Aid Formulation Development appeared first on GEN – Genetic Engineering and Biotechnology News.

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