Nature Biotechnology

Nature Biotechnology1 week ago

DNA–drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions

Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03044-0 New capabilities for controlling drug delivery into cells are developed using DNA–drug conjugates.
Nature Biotechnology2 weeks ago

Generalist biological artificial intelligence in modeling the language of life

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological...
Nature Biotechnology2 weeks ago

Functional integration of an autologous engineered esophagus in a large-animal model

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03043-1 A tissue-engineered esophageal segment is functional in minipigs.
Nature Biotechnology3 weeks ago

An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03055-x An engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO...
Nature Biotechnology3 weeks ago

Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.
Nature Biotechnology3 weeks ago

Single-molecule peptide sequencing through reverse translation of peptides into DNA

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03061-z Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.
Nature Biotechnology3 weeks ago

Balenciaga debuts eight-legged yarns

Nature Biotechnology, Published online: 17 March 2026; doi:10.1038/s41587-026-03062-y Balenciaga debuts eight-legged yarns

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Unpaired data as a first-order challenge in single-cell and spatial proteomics

Nature Biotechnology

Mapping cis-regulatory mutations at scale in sorghum enables modulation of gene expression

High-resolution metagenome assembly for modern long reads with myloasm

DNA–drug conjugates enable logic-gated drug delivery amplified by hybridization chain reactions

Generalist biological artificial intelligence in modeling the language of life

Functional integration of an autologous engineered esophagus in a large-animal model

An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy

Single-molecule peptide sequencing through reverse translation of peptides into DNA

Balenciaga debuts eight-legged yarns

FDA Reversals in Rare Disease Space Highlight Confusion Around External Controls

StockWatch: Price War Dampens Lilly Surge After Oral GLP-1 Wins FDA Nod

Pharma’s dealmaking tear; Blackstone raises record fund; Xolair energizes allergy research; and more

These ’90s fashion trends are making a comeback in 2017

The final 6 ‘Game of Thrones’ episodes might feel like a full season

According to Dior Couture, this taboo fashion accessory is back

Illinois’ financial crisis could bring the state to a halt

The final 6 ‘Game of Thrones’ episodes might feel like a full season

New Season 8 Walking Dead trailer flashes forward in time

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