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Engineering macrophage-targeted trispecific immune cell engagers for tumor immunotherapy
Nature Biotechnology, Published online: 30 March 2026; doi:10.1038/s41587-026-03104-5
Immune cell engagers (ICEs) have emerged as a promising strategy for cancer immunotherapy, but their efficacy in solid tumors remains limited, partly as a result of the difficulty of coordinating activating and inhibitory signals within the same immune cell. Here, we report a logic-gated cis-targeting strategy that enables ICEs to coordinate activating and inhibitory signals within macrophages, thereby enhancing tumor clearance in mouse models of solid cancers.
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STAT+: States looking to regulate use of chatbots
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Good morning health tech readers!
Today, a deep dive into why America’s most powerful health insurer is looking more and more like a technology company.
You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences. Sign up to get it delivered in your inbox every Tuesday and Thursday.
Good morning health tech readers!
Today, a deep dive into why America’s most powerful health insurer is looking more and more like a technology company.
Uncategorized
ARPA-H selects three teams in $100M effort to repair and regrow ailing joints
ARPA-H selects three teams in $100M effort to repair and regrow ailing joints
Three academic centers believe they may have discovered new ways to heal aging joints. Now the federal government is funding clinical trials to test these experimental regenerative medicines in osteoarthritis.
Teams from Duke University, the … Read More
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Terns sold to Merck for 13% lower than pharma’s initial offer because of clinical data
Although Merck and Terns Pharmaceuticals are part of biotech’s M&A surge, the $6.7 billion deal didn’t nearly play out the way either anticipated.
Merck decided to significantly lower its offer for the …
Illinois’ financial crisis could bring the state to a halt
The final 6 ‘Game of Thrones’ episodes might feel like a full season
New Season 8 Walking Dead trailer flashes forward in time
Mod turns ‘Counter-Strike’ into a ‘Tekken’ clone with fighting chickens
Meet Superman’s grandfather in new trailer for Krypton
Disney’s live-action Aladdin finally finds its stars
STAT+: States looking to regulate use of chatbots
ARPA-H selects three teams in $100M effort to repair and regrow ailing joints
Terns sold to Merck for 13% lower than pharma’s initial offer because of clinical data
Autoimmune Disease-Related Inflammation Reduced with ENDOtollins Drug
Gilead Swallows Another Partner, Paying up to $5B for ADC Specialist Tubulis
STAT+: Pharmalittle: We’re reading about FDA backing domestic production, another Gilead deal, and more
Illinois’ financial crisis could bring the state to a halt
The final 6 ‘Game of Thrones’ episodes might feel like a full season
New Season 8 Walking Dead trailer flashes forward in time
Mod turns ‘Counter-Strike’ into a ‘Tekken’ clone with fighting chickens
Meet Superman’s grandfather in new trailer for Krypton
Disney’s live-action Aladdin finally finds its stars
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